EWB（Extracorporeal Whole Body Hyperthermia）

EWBHは血液を体外に循環させ、その血液温度を（41.8℃～42.5℃）まで上昇させることで、直接がん細胞及びがん細胞に栄養を与えている血管も破壊する治療法です。また、この治療を行うことで、自己リンパ球を活性化させる効果もあります。そのほか、化学療法、放射線治療、遺伝子治療の効果を向上させるほか、術後の転移防止にも役立ちます。

Assessment of the effects and clinical safety of the treatment of advanced malignant tumor with extracorporeal whole body hyperthermia

【Abstract】 Objective To assay the primary effects and clinical safety of the treatment of advanced malignant tumor with extracorporeal whole body hyperthermia(EWBH)，and to evaluate the impairment of it to the vital organs and tissues.

Methods 60 patients of advanced malignant tumor were treated with EWBH and chemotherapy from June 2002 to June 2004， while the control group (n=45) with same spectrum and same stage of tumors were treated with similar chemotherapy alone. We assayed the primary effects of EWBH through comparing with controls. The stability and safety of EWBH in monitoring and controlling the body temperature were evaluated by real-time temperature measurement as well as the impairments of vital organs and tissues， such as brain， liver， kidney and lung， were by examination functional index of body peripheral blood.

Results (1) The effective rate (CR+PR+SD) of EWBH and chemotherapy was 72.6% on treating advanced malignant tumor， PD was 27.4%， the descent rate of index concerning tumor (as AFP， CER， CA199， CA242， CA125 and so on) was 72.6 %， the rate of pain relieve was 70.2%， the percentage of cases， whole body weight had increased post-EWBH after four weeks， reached 50.0%， and that of those appetite advanced was 76.5%， of those sleep improved was 56.7%. The indexes of Karnofsky was increased. 66.1%.51.2% patients alive were over one year and 80.4%over half one year. All of them are better than controls (P＜0.05). (2)Although there are some impairment on function and tissues in the vital organ， the damage is venial and reversible. (3) The method of EWBH is steadily and safe on monitoring and controlling body temperature.

Conclusion EWBH can make some reversible impair to the some vital organs and tissues， the whole procedure is steady and safe as one of hyper thermia therapy to the malignant tumor. EWBH can improve the patients live quality and prolong their life.

【Key words】 extracorporeal；whole body hyperthermia；chemotherapy；malignant tumor；effect；safety